Transferrin is a glycoprotein synthesized in the liver. Determination of transferrin level in serum and plasma is used to assess the state of iron homeostasis. An increased level of transferrin is related to iron deficiency (e.g. as a result of malnutrition or disorders of the absorption process), it may also be associated with oral hormonal contraceptives or estrogens. Transferrin deficiency is often associated with cancer, nephrotic syndrome and liver disease. Transferrin is also a negative acute phase protein, which means that its concentration decreases in inflammation. In rare cases, hereditary atransferinemia is the cause of the decreased transferrin concentration.
Transferrin measurements are helpful in monitoring the effectiveness of the iron deficiency anemia (IDA) treatment.
The specification was based on data determined on selected analyzers. We recommend that all users should refer to the instruction for use (IFU) and instruments’ user or service manuals before proceeding.
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