Urea is a product of amino acids catabolism. It is produced in liver and excreted in urine. Determination of urea level in serum, plasma and urine is mainly used as an aid in diagnosis of renal and liver diseases. Measurement of urea concentration is used to monitor patients on parenteral nutrition and differentiate prerenal and non-renal azotaemia. Urea concentration measuring is used to monitor the severity of uremic toxaemia in patients with terminal renal failure and in dialyzed patients to assess the patient's metabolic status and intensity of protein catabolism. Increased urea concentration (uremia) is observed due to dehydration, renal failure, high-protein diet, increased protein catabolism caused by tissue injury or massive bleeding into the alimentary tract. Reduced urea level could be caused by overhydration, low-protein diet or starvation and severe liver disease.
The specification was based on data determined on selected analyzers. We recommend that all users should refer to the instruction for use (IFU) and instruments’ user or service manuals before proceeding.
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