Iron is transported as Fe (III) bound to the apotransferrin. The apotransferrin-Fe (III) complex is called transferrin. Normally only about one third of the iron binding sites of transferrin are occupied by Fe (III). TIBC (Total iron-binding capacity) is a measurement for the maximum iron concentration that transferrin can bind.
Serum TIBC levels vary in disorders of iron metabolism, e.g. elevated TIBC level when iron levels are low is useful in the diagnosis and monitoring of iron deficiency anaemia and also anaemia in late pregnancy. Decreased level of TIBC may indicate disorders such as anaemia associated with chronic inflammatory disorders, haemochromatosis, other anaemias, thalassemia, cirrhosis and malignancies.
The specification was based on data determined on selected analyzers. We recommend that all users should refer to the instruction for use (IFU) and instruments’ user or service manuals before proceeding.
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