Inflammation is the body’s innate response to injury or insult, including infection, trauma, surgery, burns, and cancer. Certain proteins are released into the bloodstream during inflammation, they can be used as systemic inflammatory markers. Although there are many inflammatory markers, also known as acute phase reactants, those most commonly measured in clinical practice are C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT).
CRP (C-reactive protein) is an acute phase protein whose concentration is seen to increase as a result of the inflammatory process, most notably in response to pneumococcal (bacterial) infectious, histolytic disease and a variety of disease states. CRP to be used as a marker or general diagnostic indicator of infections and inflammation, in addition to serving as a monitor of patient response to therapy and surgery. Furthermore, regular measurements of CRP in infants can be a useful aid in the early diagnosis of infectious disease.
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