IRON

Iron is a necessary nutrient. Increased iron level can be observed in hepatic iron overload (hemochromatosis),  neonatal hemochromatosis, aceruloplasminemia, hypotransferrinemia, microcytic anemia with iron loading,  sideroblastic anemia, ferroprotein disease,  β-thalassemia. Long-term transfusion in persons treated for severe aplastic anemia, Blackfan-Diamond syndrome, Fanconi anemia, acute leukemia, autoimmune hemolytic anemias can also cause increased iron level.  Decreased values can be observed in iron deficiency anemia, anemia of chronic disease (observed in patients with infectious and inflammatory diseases - chronic kidney disease, inflammatory bowel disease, chronic heart failure, malignancies, and hepatic diseases),  gastrointestinal tumors (blood losses),  IRIDA rare (autosomal recessive) inherited disorder and obesity .