Creatine kinase (CK) catalyzes the transfer of phosphate group between creatine phosphate and adenosine diphosphate (ADP). The product of this reaction is adenosine triphosphate (ATP) – molecular source of energy. CK is a dimmer, composed of two different subunits called M and B. Three different isoenzymes formed from these subunits are found in brain and smooth muscle (BB), skeletal muscle (MM) and cardiac muscle (MM and MB). Determinations of creatine kinase MB isoenzyme (CK-MB) activity in serum are used to diagnose myocardial infarction and monitor myocardial infarction treatment. Increased creatine kinase MB isoenzyme activity can be also observed in skeletal muscle injury, chronic renal failure, overactive thyroid gland and ischemic stroke.
The specification was based on data determined on selected analyzers. We recommend that all users should refer to the instruction for use (IFU) and instruments’ user or service manuals before proceeding.
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