Creatine kinase (CK) catalyzes the transfer of phosphate group between creatine phosphate and adenosine diphosphate (ADP). Determinations of creatine kinase activity in serum are used to diagnose and monitor muscular injuries. It is also used as an aid in diagnosis of clinical conditions associated with abnormal creatine kinase activity. Increased creatine kinase activity can be observed in myocardial infarction, viral myositis, polymyositis and other muscle inflammations, muscular dystrophy, malignant hyperthermia, acute rhabdomyolysis, muscle injuries, circulatory disorders, overactive thyroid gland or kidney failure. High creatine kinase activity may also occur in infectious diseases (e.g. typhoid fever), prostate, kidney, ovary and gallbladder cancers, after surgical procedures and in damage of the muscle tissue as a consequence of intense training.
optimized kinetic, according to the International Federation of Clinical Chemistry (IFCC)
Specimen
serum
On board stability
up to 12 weeks
Calibration stability
up to 12 weeks
Measuring range
linear up to 3100 U/l
Regulatory status
CE IVD
Storage temperature (1)
2-8°C
(1) For proper storage, follow the recommended temperature range available on the label. Full details are provided in the Instructions for Use/User Manual. Transport and store at a controlled temperature in accordance with the product labeling. Deviations from the required conditions may affect the quality of the reagent.
The specification was based on data determined on selected analyzers. We recommend that all users should refer to the instruction for use (IFU) and instruments’ user or service manuals before proceeding.
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