Alkaline phosphatase (ALP) is an enzyme found in many tissues, especially bone, intestine, kidney and liver. Determinations of ALP activity in serum and plasma are mainly used as an aid in diagnosis, differentiation and monitoring of hepatobiliary disease and bone diseases. Elevated levels of the enzyme in the blood are observed, e.g. in cholestatic liver diseases, osteoporosis or Paget's disease. Decreased ALP levels are associated with Wilson's disease, hypophosphatasia and deficiency of magnesium, zinc and vitamin B12. Measurement of ALP activity is also used as a predictive marker in outcomes (death or liver transplantation) of patients with primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC).
Kinetic method recommended by International Federation of Clinical Chemistry (IFCC)
Specimen
serum, plasma
On board stability
up to 12 weeks
Calibration stability
up to 2 weeks
Measuring range
linear up to 1560 U/l
Regulatory status
CE IVD
Storage temperature (1)
2-8°C
(1) For proper storage, follow the recommended temperature range available on the label. Full details are provided in the Instructions for Use/User Manual. Transport and store at a controlled temperature in accordance with the product labeling. Deviations from the required conditions may affect the quality of the reagent.
Reagent lines
Multipurpose Line Liquick Cor-ALP 30 Liquick Cor-ALP 60 Liquick Cor- ALP 120 OS-ALP HC-ALP
ACCENT-200
ACCENT-300
A-400
A-800
Prestige 24i Prestige 24i LQ ALP (24 positions reagent tray) Prestige 24i LQ ALP (36 positions reagent tray)
The specification was based on data determined on selected analyzers. We recommend that all users should refer to the instruction for use (IFU) and instruments’ user or service manuals before proceeding.
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