Explore the Power of Blood Biochemistry in Veterinary Medicine
Biochemistry tests are a cornerstone of preventive veterinary care. In today's fast-paced veterinary medicine, the demand for accurate and timely diagnostics is higher than ever. Biochemistry tests allow for the creation of customized profiles based on the specific needs of animal patients. These profiles can be tailored according to the animal's health status and the medical procedures they undergo.
Blood biochemistry, also known as clinical chemistry, involves the blood analysis to detect and measure biochemical substances, including enzymes, electrolytes, substrates (proteins, glucose, lipids) and metabolites. These substances can reveal a great amount of information on the physiological and pathological states of an animal's body. This powerful tool makes blood biochemistry tests the indispensable tools and a cornerstone of veterinary diagnostics, offering valuable insights into an animal's health.
What can be revealed?
Organs’ function, metabolic state, general health – information on all those statuses is provided by blood chemistry tests.
There are 4 major groups of CC tests that might be distinguished:
Tests identifying organ malfunctions, for diseases diagnostics: Identifying conditions such as diabetes, liver disease, kidney failure, and electrolyte imbalances.
Tests monitoring chronic conditions: Evaluating the progression of diseases and the effectiveness of treatments.
Pre-surgical tests: Assessing an animal's health before undergoing anesthesia or surgery.
Routine healthchecking tests: Assessing the general well-being, especially important in geriatric pets or those with known health issues.
And what about health indicators?
Biochemistry tests typically analyze blood samples for key markers such as enzymes, substrates and electrolyte levels, providing crucial information for diagnosing and managing various conditions. Incorporating regular blood biochemistry tests allows practitioners to ensure a proactive approach to intervene promptly, prevent the progression of the disease and improve the prognosis. Despite monitoring the chronic diseases blood biochemistry tests can detect subclinical conditions that do not show obvious clinical symptoms initially.
Understanding the biochemical pathways and markers, specific to different species, allows veterinarians to provide precise and effective treatments. Additionally, integrating clinical observations with biochemical data ensures a comprehensive approach to animal care and its management.
Metabolic markers
General: glucose, calcium, sodium, potassium, chloride, urea, creatinine – with these parameters kidney function, acid-base balance and blood glucose levels might be assessed
Comprehensive: glucose, calcium, sodium, potassium, chloride, urea, creatinine, total protein, albumin, ALAT, ASAT, ALP and bilirubin – to evaluate organ function and metabolic status
Liver Function Markers: ALAT, ASAT, ALP, GGT, bilirubin, albumin – to check up and monitor liver function as well as diagnose hepatitis, cirrhosis, and liver tumors
Kidney Function Markers: urea, creatinine and electrolytes – to diagnose and monitor kidney diseases and assessing the severity of renal impairment
Lipid Profiles: HDL, LDL , total cholesterol and triglycerides - important for verification of lipid metabolism disorders, leading to conditions like pancreatitis and cardiovascular diseases.
What can be revealed? Case Studies
DOGS - Diagnosing Liver Disease
Chronic hepatitis
A middle-aged dog patient presents with jaundice and lethargy. Blood biochemistry reveals elevated ALAT, ASAT, and bilirubin levels, suggesting liver disease. Continued diagnostics, supported with imaging and biopsy confirm chronic hepatitis.
CATS – Renal diseases
Monitoring health status and treatment adjustments
An older cat with a history of chronic kidney disease undergoes regular blood tests. Elevated urea and creatinine levels, along with observed electrolyte imbalances, indicate worsening kidney function. In depth and regular insight in blood chemistry markers prompts adjustments in treatment.
HORSES - Diabetes
Disease management
A horse exhibiting signs of polyuria and polydipsia is tested for glucose and insulin levels. Blood tests show hyperglycemia and insulin resistance, leading to a diagnosis of equine metabolic syndrome. Dietary changes and medication are implemented to manage the condition.
How to tests so many markers to a large and versatile patients group?
Veterinary medicine utilizes state-of-the-art technology advancements of in vitro diagnostics world. Innovations enhance accuracy and efficiency of blood biochemistry tests. Moreover, modern solutions bring facilitaion to everyday work through:
Automation - Reducing human error and increasing throughput.
Cito mode testing - Allowing for immediate results in critical situations.
Therefore, despite blood biochemistry limitations like patient’s group variability, differences in reference ranges among the species, interfering substances and sample quality, as well as non-specific results, because some pathologies might be observed in multiple diseases, conducting blood chemistry tests in everyday veterinarian practice is obligatory. Those indispensable tools in veterinary medicine, offer valuable insights into an animal's health and are a fundamental aspect of veterinary diagnostics, providing critical information for the diagnosis and management of various health conditions in animals. Understanding the different types of tests, proper sample handling, and interpretation of results are essential skills for veterinarians to provide the best possible care for their patients.
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